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A single dose of dezocine suppresses emergence agitation in preschool children anesthetized with sevoflurane-remifentanil.
- Source :
-
BMC Anesthesiology . 11/22/2017, Vol. 17, p1-6. 6p. - Publication Year :
- 2017
-
Abstract
- Background: Emergence agitation (EA) is a common phenomenon in preschool children during emergence from general anesthesia. This study evaluated the safety and efficacy of dezocine for emergence agitation in preschool children anesthetized with sevoflurane-remifentanil. Methods: A total of 100 preschool children, scheduled for elective laparoscopic repair of an inguinal hernia by high ligation of the hernia sac under sevoflurane-remifentanil anesthesia were randomized into two groups: Group C(n = 50) received Ringer's lactate 10 mL and Group D received Ringer's lactate 10 mL containing dezocine 0.1 mg/kg, postoperatively. Results: Incidence of EA, defined as a score ≥ 3onAono's four point scale or Pediatric Anesthesia Emergence Delirium (PAED) score ≥ 10 in the PACU (10% vs. 76%) and the percentage of patients with severe EA (PAED score ≥ 13) (12% vs. 76%) were significantly lower in Group D compared to Group C (P < 0.05). Mean Children and Infants Postoperative Pain Scale (CHIPPS) score was significantly lower in Group D compared to Group C (1.2 ± 0.5 vs. 5.2 ± 0.6; P < 0.05). Patients need for fentanyl (18% vs. 4%) or propofol rescue (20% vs. 0) was significantly greater in Group C compared to Group D. No significant differences in other relative aspects after surgery between groups. Conclusion: Administration of dezocine 0.1 mg/kg decreased the incidence and severity of EA in preschool children that had undergone laparoscopic repair of an inguinal hernia by high ligation of the hernia sac under sevoflurane-remifentanil anesthesia. Trial registration: A single dose of dezocine suppresses emergence agitation in preschool children anesthetized with sevoflurane-remifentanil effectively: A double-blind, prospective, randomized, controlled study, Chinese Clinical Trial Registry (ID: ChiCTR-IOR-16010033), retrospectively registered on November 21, 2016. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of narcotics
*INGUINAL hernia
*ANALGESICS
*BLOOD plasma substitutes
*DELIRIUM
*FENTANYL
*LAPAROSCOPIC surgery
*LOCAL anesthetics
*LONGITUDINAL method
*NARCOTICS
*POSTOPERATIVE pain
*RANDOMIZED controlled trials
*DISEASE incidence
*BLIND experiment
*SEVERITY of illness index
*PROPOFOL
*SEVOFLURANE
*CHILDREN
*SURGERY
Subjects
Details
- Language :
- English
- ISSN :
- 14712253
- Volume :
- 17
- Database :
- Academic Search Index
- Journal :
- BMC Anesthesiology
- Publication Type :
- Academic Journal
- Accession number :
- 126955842
- Full Text :
- https://doi.org/10.1186/s12871-017-0446-8