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Inter-individual responses to sprint interval training, a pilot study investigating interactions with the sirtuin system.
- Source :
-
Applied Physiology, Nutrition & Metabolism . 2018, Vol. 43 Issue 1, p84-93. 10p. 5 Charts, 5 Graphs. - Publication Year :
- 2018
-
Abstract
- Sprint interval training (SIT) is reported to improve blood glucose control and may be a useful public health tool. The sirtuins and associated genes are emerging as key players in blood glucose control. This study investigated the interplay between the sirtuin/NAD system and individual variation in insulin sensitivity responses after SIT in young healthy individuals. Before and after 4 weeks of SIT, body mass and fat percentage were measured and oral glucose tolerance tests performed in 20 young healthy participants (7 females). Blood gene expression profiles (all 7 mammalian sirtuin genes and 15 enzymes involved in conversion of tryptophan, bioavailable vitamin B3, and metabolic precursors to NAD). NAD/NADP was measured in whole blood. Significant reductions in body weight and body fat post-SIT were associated with altered lipid profiles, NAD/NADP, and regulation of components of the sirtuin/NAD system ( NAMPT, NMNAT1, CD38, and ABCA1). Variable improvements in measured metabolic health parameters were evident and attributed to different responses in males and females, together with marked inter-individual variation in responses of the sirtuin/NAD system to SIT. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17155312
- Volume :
- 43
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Applied Physiology, Nutrition & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 127059789
- Full Text :
- https://doi.org/10.1139/apnm-2017-0224