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Remote-3DD: un nuevo método para la detección de homólogos remotos que usa propiedades fisicoquímicas.
- Source :
-
Ingeniería y Competitividad . 2017, Vol. 19 Issue 2, p25-35. 11p. - Publication Year :
- 2017
-
Abstract
- In this paper, we present a new method for remote homology detection called remote-3DD. The proposed method combines predicted contact maps and distributions of the interaction matrices. Predicted contact maps approximate the 3D shape of a protein based on its primary structure. On the other hand, an interaction matrix allows representing a protein by using the physicochemical properties of its amino acids. The remote-3DD method is proposed as a strategy to improve the accuracy of the remote-C3D method, which uses contact maps alone. In this paper, we hypothesize that we can improve the accuracy of the remote-C3D method by including physicochemical properties. The results show that the accuracy of the remote-3DD method is higher than the accuracy of the composition-based methods and in some cases comparable with the accuracy of the profilebased methods. In addition, the results also show that the remote-3DD method achieves higher accuracy values than the remote-C3D method when considering the same number of models and size of submatrices. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01233033
- Volume :
- 19
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Ingeniería y Competitividad
- Publication Type :
- Academic Journal
- Accession number :
- 127104101
- Full Text :
- https://doi.org/10.25100/iyc.v19i2.5289