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The significance of neonatal thymectomy for shaping the immune system in children with congenital heart defects.
- Source :
-
Polish Journal of Thoracic & Cardiovascular Surgery / Kardiochirurgia i Torakochirurgia Polska . 2017, Vol. 14 Issue 4, p258-162. 5p. - Publication Year :
- 2017
-
Abstract
- The thymus plays an important role in the development of the immune cell pool; it serves as the primary location for T-lymphocyte maturation. Early cardiac surgical interventions for congenital heart defects are necessarily associated with thymectomy, i.e. the partial or complete removal of the thymus. A newborn infant already has a functioning thymus and developed cells of the immune system. However, thymectomy eliminates the primary location where T cells differentiate and mature. This study summarizes the current knowledge of the cellular disturbances and potential clinical consequences associated with performing thymectomy in children treated surgically for congenital heart defects. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17315530
- Volume :
- 14
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Polish Journal of Thoracic & Cardiovascular Surgery / Kardiochirurgia i Torakochirurgia Polska
- Publication Type :
- Academic Journal
- Accession number :
- 127156845
- Full Text :
- https://doi.org/10.5114/kitp.2017.72231