低分子肝素钙联合银杏达莫注射液应用于股骨粗隆间骨折术后下肢深静 脉血栓形成的疗效观察

Objective: To investigate the treatment effect of low molecular weight heparin calcium combined with Ginkgo Leaf Extract and Dipyridamole Injection on the lower extremity deep femoral intertrochanteric fracture postoperative venous thrombosis treatment. Methods: Selected SO patients with femoral intertrochanteric fractures at department of orthopedics in our hospital from June 2015 to December 2016, which were randomly divided into study group (n=40) and control group (n=40) according to the random number table method. Patients of two groups were treated with surgical treatment. The control group was treated with low molecular weight heparin calcium 6000IU after surgery, subcutaneous injection. 2 times/d: The study group were treated with Ginkgo Leaf Extract and Dipyridamole Injection 20 mL on the basis of the control group, intravenous drip. 1time/d. and the course of treatment in two groups was l0d. Observed incidence of lower extremity deep venous thrombosis, the 15 cm diameter and the swelling rate of the upper pole of the patella and the inferior pole of the patella of patients in two groups after surgery, the prothrombin time (PT), activated partial thromboplastin time (APPT). D-dimer (D-D) levels and blood rheology examination index before and after treatment. Results: The incidence of lower extremity deep venous thrombosis in the study group was 2.50%, which was lower than that 15.00% in the control group (P<0.05). After treatment, 15 cm diameter of the superior pole of the patella and the 15cm diameter of the inferior pole of the patella of patients in two groups were increased slightly, and there was no statistical difference compared with before treatment (P>0.05). There was no significant difference between the two groups in the swelling rate of 15 cm on the upper pole of the patella and 15 cm in the inferior pole of the patella (PX1.05). PT and APPT of patients in the study group were significantly higher than the control group at 2 d after treatment, and D-D was significantly lower than the control group (P<0.05). At l0d after treatment, APPT and PT were significantly higher than the control group, D-D was significantly lower than the control group (P<0.05). At 2d, l0d after treatment, the whole blood high and low shear blood plasma viscosity, hematocrit, erythrocyte aggregation index and fibrinogen in study group were significantly lower than the control group (P<0.05). Conclusion: Low molecular weight heparin calcium combined with Ginkgo Leaf Extract and Dipyridamole Injection can reduce blood coagulation, improve blood rheology, which has a good effect on prevention of deep vein thrombosis of lower extremity in patients with femoral intertrochanteric fractures. [ABSTRACT FROM AUTHOR]