Back to Search
Start Over
Epidermal Keratiocytes Express the Adhesion Molecule Intercellular Adhesion Molecule-1 in Inflammatory Dermatoses.
- Source :
-
Journal of Investigative Dermatology . May89, Vol. 92 Issue 5, p746-750. 5p. - Publication Year :
- 1989
-
Abstract
- Using indirect immunofluorescence assays on frozen tissue sections of skin from healthy subjects and subjects with inflammatory skin diseases, we found that intercellular adhesion molecule-1 (ICAM- 1) was expressed in a cell surface pattern on epidermal keratinocytes at the site of lymphoid infiltration in cutaneous dermatoses. ICAM-1 was not expressed on epidermal keratinocytes in noninflamed skin. Its expression was not related solely to epidermal hyperproliferation, as hyperproliferative, tape-stripped epidermis did not express ICAM-1. We have reported previously that ICAM-1 expression on epidermal keratinocytes was upregulated by treatment with interferon gamma and that activated T lymphocytes bound to cultured epidermal keratinocytes in vitro by lymphocyte function associated-1 (LFA-1) molecules on T cells and ICAM-1 on epidermal keratinocytes. Taken together, these data suggest that upregulation of expression of ICAM-1 is an important feature of cutaneous inflammation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SKIN diseases
*IMMUNOGLOBULINS
*INTERFERONS
*KERATINOCYTES
*LYMPHOCYTES
*EPITHELIUM
Subjects
Details
- Language :
- English
- ISSN :
- 0022202X
- Volume :
- 92
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Investigative Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 12722441
- Full Text :
- https://doi.org/10.1016/0022-202X(89)90193-0