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Placental oxidative stress and maternal endothelial function in pregnant women with normotensive fetal growth restriction.
- Source :
-
Journal of Maternal-Fetal & Neonatal Medicine . Apr2018, Vol. 31 Issue 8, p1051-1057. 7p. - Publication Year :
- 2018
-
Abstract
- <bold>Objective: </bold>The purpose of this study was to investigate the relationship between placental oxidative stress and maternal endothelial function in pregnant women with normotensive fetal growth restriction (FGR).<bold>Methods: </bold>We examined serum concentrations of oxygen free radicals (d-ROMs), maternal angiogenic factor (PlGF), and sFlt-1, placental oxidative DNA damage, and maternal endothelial function in 17 women with early-onset preeclampsia (PE), 18 with late-onset PE, 14 with normotensive FGR, and 21 controls. Flow-mediated vasodilation (FMD) was assessed as a marker of maternal endothelial function. Immunohistochemical analysis was performed to measure the proportion of placental trophoblast cell nuclei staining positive for 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage.<bold>Results: </bold>Maternal serum d-ROM, sFlt-1 concentrations, and FMD did not significantly differ between the control and normotensive FGR groups. The proportion of nuclei staining positive for 8-OHdG was significantly higher in the normotensive FGR group relative to the control group.<bold>Conclusions: </bold>Our findings demonstrate that, despite the presence of placental oxidative DNA damage as observed in PE patients, pregnant women with normotensive FGR show no increase in the concentrations of sFlt-1 and d-ROMs, or a decrease in FMD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14767058
- Volume :
- 31
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Maternal-Fetal & Neonatal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 127266652
- Full Text :
- https://doi.org/10.1080/14767058.2017.1306510