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Isocanthine Synthesis via Rh(III)-Catalyzed Intramolecular C-H Functionalization.
- Source :
-
Journal of Organic Chemistry . 1/5/2018, Vol. 83 Issue 1, p330-337. 8p. - Publication Year :
- 2018
-
Abstract
- An efficient synthesis of substituted isocanthines has been achieved using an intramolecular Rh(III)-catalyzed C-H functionalization of alkyne-tethered indoles in the presence of catalytic tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate and stoichiometric copper(II) acetate. This isocanthine synthesis tolerates a variety of electronically diverse 5- or 6-substituted indoles with N-tethered alkyne coupling partners and can also be extended to pyrrole derivatives for the synthesis of annulated 5-azaindoles. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 83
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 127281050
- Full Text :
- https://doi.org/10.1021/acs.joc.7b02731