Back to Search
Start Over
Sex differences and estradiol involvement in hyperalgesia and allodynia in an experimental model of fibromyalgia.
- Source :
-
Hormones & Behavior . Jan2018, Vol. 97, p39-46. 8p. - Publication Year :
- 2018
-
Abstract
- Fibromyalgia (FM) is a musculoskeletal chronic pain syndrome. Its prevalence in women is higher than in men possibly by hormonal factors given that symptoms are aggravated during sex hormone-related events, such as the premenstrual period, pregnancy, postpartum or menopause. The aim of the present study was to investigate whether hyperalgesia and allodynia, in reserpine-induced experimental FM, depend on sex, estrous cycle, ovariectomy and replacement with 17β-estradiol. To fulfill this objective, we compared males, intact females with known estrous cycle phases and ovariectomized (OVX) rats treated with 17β-estradiol. Data demonstrated that reserpine administration disrupted the normal estrous cycle and produced that all females entered metestrus/diestrus. In addition, this treatment leads to muscle hyperalgesia and tactile allodynia in a similar manner in male and intact female rats. However, the absence of ovarian hormones (in OVX rats) increased muscle nociception. 17β-estradiol (2.5–10 μg/rat) produced antihyperalgesic and antiallodynic effects 24 h, but not 8 h, after its administration, suggesting a genomic mechanism. The present results support the validity of the reserpine-induced FM model for searching alternatives of treatment, particularly during endocrine phases when pain is exacerbated such as menopause, and that 17β-estradiol replacement might be useful. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FIBROMYALGIA
*ESTRADIOL
*HYPERALGESIA
*ALLODYNIA
*MENOPAUSE
*RESERPINE
Subjects
Details
- Language :
- English
- ISSN :
- 0018506X
- Volume :
- 97
- Database :
- Academic Search Index
- Journal :
- Hormones & Behavior
- Publication Type :
- Academic Journal
- Accession number :
- 127285513
- Full Text :
- https://doi.org/10.1016/j.yhbeh.2017.10.011