跑台运动对阿霉素联合醋酸戈舍瑞林诱导骨质疏松大鼠骨密度和骨代谢的影响

Objective To explore the effects of doxorubicin (DOX) combined with goserelin acetate (GA) on bone mineral density and bone metabolism of rats, as well as the prevention effect of treadmill exercise on doxorubicin and goserelin acetate-induced osteoporosis. Methods Sixty-four 8-week-old male SD rats were randomly divided into 8 groups: sedentary control group (SED), DOX intervention group (SED+DOX), GA intervention group (SED+GA), DOX combined GA intervention group (SED+DOX+GA), treadmill exercise control group (EX), treadmill exercise and DOX intervention group (EX+DOX), treadmill exercise and GA intervention group (EX+GA), and treadmill exercise and DOX combined GA intervention group (EX+DOX+GA). Drug and treadmill exercise intervention period was 8 weeks. After 8 weeks, BMD of the left femur and serum bone metabolic markers of rats were tested. Results Compared to their corresponding non-pharmacological intervention groups, BMD and the bone formation indicators BGP and ALP in the DOX and GA intervention groups decreased significantly, and the bone resorption indicators Ca2+ and TRACP5b in the DOX and GA intervention groups increased significantly. Compared to DOX or GA intervention alone, combined DOX and GA intervention significantly decreased BMD and bone formation indicators ALP and BGP, and increased the bone resorption indicators Ca2+ and TRACP5b of the rats. Compared to their corresponding sedentary groups, BMD and the bone formation indicators BGP and ALP of the treadmill exercise groups increased significantly, and the bone resorption indicators Ca2+ and TRACP5b of the treadmill exercise groups decreased significantly. Conclusion DOX and GA alone or combination can lead to osteoporosis in rats, and the extent of osteoporosis was significantly greater in the combined DOX and GA-induced rats than in rat of DOX or GA used alone. Treadmill exercise can effectively reduce DOX and GA alone or their combination-induced osteoporosis. [ABSTRACT FROM AUTHOR]