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Detection of breed-specific copy number variations in domestic chicken genome.
- Source :
-
Genome . 2018, Vol. 61 Issue 1, p7-14. 8p. - Publication Year :
- 2018
-
Abstract
- Copy number variations (CNVs) are important large-scale variants. They are widespread in the genome and may contribute to phenotypic variation. Detection and characterization of CNVs can provide new insights into the genetic basis of important traits. Here, we perform whole-genome short read sequence analysis to identify CNVs in two indigenous and commercial chicken breeds to evaluate the impact of the identified CNVs on breed-specific traits. After filtration, a total of 12 955 CNVs spanning (on average) about 9.42% of the chicken genome were found that made up 5467 CNV regions (CNVRs). Chicken quantitative trait loci (QTL) datasets and Ensembl gene annotations were used as resources for the estimation of potential phenotypic effects of our CNVRs on breed-specific traits. In total, 34% of our detected CNVRs were also detected in earlier CNV studies. These CNVRs partly overlap several previously reported QTL and gene ontology terms associated with some important traits, including shank length QTL in Creeper-specific CNVRs and body weight and egg production characteristics, as well as muscle and body organ growth, in the Arian commercial breed. Our findings provide new insights into the genomic structure of the chicken genome for an improved understanding of the potential roles of CNVRs in differentiating between breeds or lines. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DNA copy number variations
*CHICKENS
*GENOMES
*PHENOTYPES
*BREEDING
Subjects
Details
- Language :
- English
- ISSN :
- 08312796
- Volume :
- 61
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Genome
- Publication Type :
- Academic Journal
- Accession number :
- 127325683
- Full Text :
- https://doi.org/10.1139/gen-2017-0016