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Accelerated Blood Clearance (ABC) Phenomenon Favors the Accumulation of Tartar Emetic in Pegylated Liposomes in BALB/c Mice Liver.

Authors :
Lopes, Tamara C. M.
Silva, Débora F.
Costa, Walyson C.
Frézard, Frédéric
Barichello, José M.
Silva-Barcellos, Neila M.
Lima, Wanderson G. de
Rezende, Simone A.
Source :
Pathology Research International. 1/16/2018, p1-7. 7p.
Publication Year :
2018

Abstract

Tartar emetic (TE) was the first drug used to treat leishmaniasis. However, its use was discontinued due to high toxicity. Association of TE with liposomes is a strategy to reduce its side effects. Pegylated liposomes (Lpeg) present lower rates of uptake by macrophages and prolonged circulation compared to their nonpegylated counterparts. However, repeated administration of Lpeg can cause an Accelerated Blood Clearance (ABC) phenomenon, whereby recognition of liposomes by antibodies results in faster phagocytosis. This work evaluated the effect of TE administration on histopathological aspects and the effect of the ABC phenomenon on targeting and toxicity in mice. Our results show that treatment with free or liposomal TE had no effect on the erythrocyte count, on liver and spleen weight, and on hepatic, splenic, and cardiac histology in mice. Severe lesions were observed on the kidneys of animals treated with a single dose of free TE. Treatment with TE in Lpeg after induction of ABC phenomenon caused a significant increase in Sb level in the liver without toxicity. Furthermore, mice treated with TE in liposomes showed normal renal histopathology. These results suggest site-specific targeting of Sb to the liver after induction of ABC phenomenon with no toxicity to other organs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20908091
Database :
Academic Search Index
Journal :
Pathology Research International
Publication Type :
Academic Journal
Accession number :
127336483
Full Text :
https://doi.org/10.1155/2018/9076723