Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either <italic>LMAN1</italic> or <italic>MCFD2,</italic> in a Japanese family.

The article discusses an increased frequency of a rare bleeding disorder, which is a combined deficiency of two blood coagulation factors, in regions where consanguineous marriage is practiced. According to the author, this rare bleeding disorder, which is a combination of parahaemophilia and haemophilia A is usually caused by mutations of lectin mannose binding 1 (LMAN1) and multiple coagulation factor deficiency 2 (MCFD2).