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Platelet Count before Peripheral Blood Stem Cell Mobilization Is Associated with the Need for Plerixafor But Not with the Collection Result.
- Source :
-
Transfusion Medicine & Hemotherapy . Jan2018, Vol. 45 Issue 1, p24-31. 8p. - Publication Year :
- 2018
-
Abstract
- Background: A low platelet count before mobilization has recurrently been identified as risk factor for poor mobilization. Methods: To determine the relevance of this finding for peripheral blood stem cell (PBSC) mobilization, including pre-emptive or rescue plerixafor in the case of poor mobilization, we retrospectively analyzed all patients undergoing PBSC collection at our institution between January 2014 and December 2015 (n = 380). Results: In total, 99% of the patients (377/380) successfully collected a minimum of 2 × 106 CD34+ cells/kg body weight sufficient for a single transplant. Rescue or pre-emptive plerixafor was administered to 11% of the patients (42/380). No correlations between the platelet count before mobilization and the number of peripheral blood CD34+ cells or the CD34+ cell collection result were detected in the entire population or the subgroups according to diagnosis (newly diagnosed multiple myeloma, relapsed multiple myeloma, lymphoma, amyloid light-chain amyloidosis, sarcoma, or germ cell tumor). However, patients requiring pre-emptive or rescue plerixafor had a significantly lower platelet count before mobilization (217/nl vs. 245/nl; p = 0.004). Conclusion: With the current state of the art PBSC mobilization strategies, the platelet count before mobilization was not associated with the CD34+ cell collection result but was associated with the need for pre-emptive or rescue application of plerixafor. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD platelets
*BLOOD transfusion
*LEUCOCYTES
*BLOOD cell count
*BONE marrow
Subjects
Details
- Language :
- English
- ISSN :
- 16603796
- Volume :
- 45
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Transfusion Medicine & Hemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 127707488
- Full Text :
- https://doi.org/10.1159/000478911