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Preparation of N, N, N-trimethyl chitosan-functionalized retinoic acid-loaded lipid nanoparticles for enhanced drug delivery to glioblastoma.
- Source :
-
Tropical Journal of Pharmaceutical Research . Aug2017, Vol. 16 Issue 8, p1765-1772. 8p. - Publication Year :
- 2017
-
Abstract
- Purpose: To formulate trimethyl chitosan-functionalized retinoic acid-encapsulated solid lipid nanoparticles for the effective treatment of glioma. Methods: Retinoic acid-loaded solid lipid nanoparticles (R-SLNs) were prepared using homogenization followed by sonication. R-SLN surfaces were functionalized electrostatically with trimethyl chitosan as a nanocarrier (TR-SLNs) with enhanced anti-cancer activity. They were evaluated by dynamic light scattering (DLS), scanning electron microscopy, in vitro drug release, and cell cytotoxicity and apoptosis studies. Results: Morphological images showed spherical and uniformly dispersed nanoparticles. A sustained monophasic release pattern was observed throughout the study period. Furthermore, the anti-cancer effect of TR-SLNs was demonstrated by increased cell killing activity compared with the free drug (p < 0.01); negligible cytotoxicity was observed with blank carriers. Apoptosis assay showed increased cell populations in early/late apoptotic and necrotic phases. Conclusion: This study showed the potential application of surface-modified solid lipid nanoparticles for the effective treatment of brain cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHITOSAN
*LIPIDS
*NANOPARTICLES
*GLIOBLASTOMA multiforme
*DRUG delivery systems
Subjects
Details
- Language :
- English
- ISSN :
- 15965996
- Volume :
- 16
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Tropical Journal of Pharmaceutical Research
- Publication Type :
- Academic Journal
- Accession number :
- 127710466
- Full Text :
- https://doi.org/10.4314/tjpr.v16i8.3