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AID Biology: A pathological and clinical perspective.

Authors :
Choudhary, Meenal
Tamrakar, Anubhav
Singh, Amit Kumar
Jain, Monika
Jaiswal, Ankit
Kodgire, Prashant
Source :
International Reviews of Immunology. 2018, Vol. 37 Issue 1, p37-56. 20p.
Publication Year :
2018

Abstract

Activation-induced cytidine deaminase (AID), primarily expressed in activated mature B lymphocytes in germinal centers, is the key factor in adaptive immune response against foreign antigens. AID is responsible for producing high-affinity and high-specificity antibodies against an infectious agent, through the physiological DNA alteration processes of antibody genes by somatic hypermutation (SHM) and class-switch recombination (CSR) and functions by deaminating deoxycytidines (dC) to deoxyuridines (dU), thereby introducing point mutations and double-stranded chromosomal breaks (DSBs). The beneficial physiological role of AID in antibody diversification is outweighed by its detrimental role in the genesis of several chronic immune diseases, under non-physiological conditions. This review offers a comprehensive and better understanding of AID biology and its pathological aspects, as well as addresses the challenges involved in AID-related cancer therapeutics, based on various recent advances and evidence available in the literature till date. In this article, we discuss ways through which our interpretation of AID biology may reflect upon novel clinical insights, which could be successfully translated into designing clinical trials and improving patient prognosis and disease management. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08830185
Volume :
37
Issue :
1
Database :
Academic Search Index
Journal :
International Reviews of Immunology
Publication Type :
Academic Journal
Accession number :
127727918
Full Text :
https://doi.org/10.1080/08830185.2017.1369980