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Synthesis of Phenols: Organophotoredox/Nickel Dual Catalytic Hydroxylation of Aryl Halides with Water.
- Source :
-
Angewandte Chemie . 2/12/2018, Vol. 130 Issue 7, p1986-1990. 5p. - Publication Year :
- 2018
-
Abstract
- Abstract: A highly effective hydroxylation reaction of aryl halides with water under synergistic organophotoredox and nickel catalysis is reported. The OH group of the resulting phenols originates from water, following deprotonation facilitated by an intramolecular base group on the ligand. Significantly, aryl bromides as well as less reactive aryl chlorides served as effective substrates to afford phenols with a wide range of functional groups. Without the need for a strong inorganic base or an expensive nobleāmetal catalyst, this process can be applied to the efficient preparation of diverse phenols and enables the hydroxylation of multifunctional pharmaceutically relevant aryl halides. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHENOL synthesis
*NICKEL catalysts
*HYDROXYLATION
*ARYL halides
*FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 130
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 127847719
- Full Text :
- https://doi.org/10.1002/ange.201710698