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Association between <bold><italic>IL-13</italic></bold> Gene rs20541 Polymorphism and Glioma Susceptibility: A Meta-Analysis.
- Source :
-
Oncology Research & Treatment . Feb2018, Vol. 41 Issue 1, p14-21. 8p. - Publication Year :
- 2018
-
Abstract
- Objective: We performed a meta-analysis to estimate the association between IL-13 gene rs20541 (R130Q) polymorphism and the susceptibility of glioma. Patients and Methods: Potentially eligible studies published before February 1, 2016 were searched in 4 databases including PubMed, EMBASE, EBSCO, and Ovid. Odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were used to estimate the strength of relationship between the IL-13 gene rs20541 polymorphism and glioma susceptibility. Stata 11.0 software was used to perform the present meta-analysis. Results: In total, 10 case-control studies with 13 datasets including 3,123 cases and 5,390 controls were identified. A significant increase in glioma susceptibility was found in the dominant model (AA + AG vs. GG: OR = 1.14, 95% CI 1.01-1.29; P = 0.031). Significantly decreasing glioma susceptibility was found for Asians in the heterozygote comparison (AG vs. GG: OR = 0.74, 95% CI 0.55-0.99; P = 0.042) and the allele contrast genetic model (A vs. G: OR = 0.67, 95% CI 0.47-0.96; P = 0.028). By contrast, in Caucasians, a significant increase in glioma susceptibility was found in the dominant model (AA + AG vs. GG: OR = 1.25, 95% CI 1.11-1.41; P = 0.000). Conclusion: There may be a weak association between the IL-13 gene rs20541 polymorphism and glioma susceptibility, and the associations may be different between ethnicities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22965270
- Volume :
- 41
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Oncology Research & Treatment
- Publication Type :
- Academic Journal
- Accession number :
- 127892296
- Full Text :
- https://doi.org/10.1159/000480518