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A six-step synthetic approach to marine natural product (+)-aureol.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Mar2018, Vol. 59 Issue 10, p945-948. 4p. - Publication Year :
- 2018
-
Abstract
- A concise synthetic approach to the marine natural product (+)-aureol has been achieved from readily available starting materials using obviously fewer steps in comparison to the related report in literature (6 steps versus 12 steps from (+)-sclareolide). Key steps of this protocol include a boron trifluoride-catalyzed domino 1,2-H and 1,2-methyl shifts and a nickel(II)-catalyzed cross-coupling reaction between an alkyl iodide and an aryl Grignard reagent. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NATURAL products
*BIOSYNTHESIS
*BORON trifluoride
*CATALYSIS
*GRIGNARD reagents
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 59
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 127919623
- Full Text :
- https://doi.org/10.1016/j.tetlet.2018.01.091