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Right-to-left shunt and subclinical ischemic brain lesions in Chinese migraineurs: a multicentre MRI study.
- Source :
-
BMC Neurology . 2/14/2018, Vol. 18, p1-7. 7p. 1 Color Photograph, 1 Diagram, 3 Charts, 1 Graph. - Publication Year :
- 2018
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Abstract
- <bold>Background: </bold>Migraine is considered as a risk factor for subclinical brain ischemic lesions, and right-to-left shunt (RLS) is more common among migraineurs. This cross-sectional study assessed the association of RLS with the increased prevalence of subclinical ischemic brain lesions in migraineurs.<bold>Methods: </bold>We enrolled 334 migraineurs from a multicentre study from June 2015 to August 2016. Participants were all evaluated using contrast-enhanced transcranial Doppler, magnetic resonance imaging (MRI), and completed a questionnaire covering demographics, the main risk factors of vascular disease, and migraine status. RLS was classified into four grades (Grade 0 = Negative; Grade I = 1 ≤ microbubbles (MBs) ≤ 10; Grade II = MBs > 10 and no curtain; Grade III = curtain). Silent brain ischemic infarctions (SBI) and white matter hyperintensities (WMHs) were evaluated on MRI.<bold>Results: </bold>We found no significant differences between migraineurs with RLS and migraineurs without RLS in subclinical ischemic brain lesions.SBI and WMHs did not increase with the size of the RLS(p for trend for SBI = 0.066, p for trend for WMHs = 0.543). Furthermore, curtain RLS in migraineurs was a risk factor for the presence of SBI (p = 0.032, OR = 3.47; 95%CI: 1.12-10.76). There was no association between RLS and the presence of WMHs.<bold>Conclusion: </bold>Overall, RLS is not associated with increased SBI or WMHs in migraineurs. However, when RLS is present as a curtain pattern, it is likely to be a risk factor for SBIs in migraineurs.<bold>Trial Registration: </bold>No. NCT02425696 ; registered on April 21, 2015. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MIGRAINE
*WHITE matter (Nerve tissue)
*BRAIN imaging
*MAGNETIC resonance imaging
*DISEASE prevalence
*VASCULAR diseases
*DISEASE risk factors
*ATRIAL septal defects
*BRAIN
*CEREBRAL ischemia
*COMPARATIVE studies
*DEGENERATION (Pathology)
*INFARCTION
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*TRANSCRANIAL Doppler ultrasonography
*EVALUATION research
*EQUIPMENT & supplies
*CROSS-sectional method
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 14712377
- Volume :
- 18
- Database :
- Academic Search Index
- Journal :
- BMC Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 128022970
- Full Text :
- https://doi.org/10.1186/s12883-018-1022-7