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Changes in Neuronal Signaling and Cell Stress Response Pathways are Associated with aMultigenic Response of Drosophila melanogaster to DDT Selection.
- Source :
-
Genome Biology & Evolution . Dec2017, Vol. 9 Issue 12, p3356-3372. 17p. - Publication Year :
- 2017
-
Abstract
- The adaptation of insect populations to insecticidal control is a continual threat to human health and sustainable agricultural practices, butmany complex genomicmechanisms involved in this adaption remain poorly understood. This study applied a systems approach to investigate the interconnections between structural and functional variance in response to dichlorodiphenyltrichloroethane (DDT) within the Drosophila melanogaster strain 91-R. Directional selection in 6 selective sweeps coincided with constitutive gene expression differences in DDT resistant flies, including the most highly upregulated transcript, Unc-115 b, which plays a central role in axon guidance, and the most highly downregulated transcript, the angiopoietin-like CG31832, which is involved in directing vascular branching and dendrite outgrowth but likely may be under trans-regulatory control. Direct functions and protein--protein interactions mediated by differentially expressed transcripts control changes in cellmigration, signal transduction, and gene regulatory cascades that impact the nervous system. Although changes to cellular stress response pathways involve 8 different cytochrome P450s, stress response, and apoptosis is controlled by a multifacetted regulatory mechanism. These data demonstrate that DDT selection in 91-R may have resulted in genome-wide adaptations that impacts genetic and signal transduction pathways that converge to modify stress response, cell survival, and neurological functions. This study implicates the involvement of a multigenic mechanism in the adaptation to a chemical insecticide, which impact interconnected regulatory cascades. We propose that DDT selection within 91-R might act systemically, wherein pathway interactions function to reinforce the epistatic effects of individual adaptive changes on an additive or nonadditive basis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17596653
- Volume :
- 9
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Genome Biology & Evolution
- Publication Type :
- Academic Journal
- Accession number :
- 128029048
- Full Text :
- https://doi.org/10.1093/gbe/evx252