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Clinical factors are associated with vitamin D levels in IBD patients: A retrospective analysis.
- Source :
-
Journal of Digestive Diseases . Jan2018, Vol. 19 Issue 1, p24-32. 9p. - Publication Year :
- 2018
-
Abstract
- OBJECTIVE: There is growing evidence that vitamin D deficiency plays a role in the development and the course of inflammatory bowel disease (IBD). However, the correlation between vitamin D deficiency and clinical parameters in IBD is still not completely understood. METHODS: A retrospective study of IBD patients was performed. Vitamin D values were analyzed, regardless of vitamin D substitution administration, and correlated with clinical parameters such as medical therapy, anatomical situation, location of the disease and disease activity. Level of 25‐hydroxyvitamin D [25(OH)D] <50 nmoL/L was regarded as vitamin D deficiency and <75 nmoL/L as insufficiency. RESULTS: In total, 208 IBD patients were analyzed, including 123 with Crohn's disease (CD) and 85 with ulcerative colitis (UC). Therapy with azathioprine did not affect the vitamin D values of either disease entity. But CD patients benefited from therapy with tumor necrosis factor‐α inhibitor and exhibited significantly higher vitamin D levels than those without. Furthermore, significantly lower vitamin D levels were found if CD was located in the small bowel or if the small bowel had been resected. Moreover, significantly lower levels of vitamin D were detectable for high disease activity (reflected by high simple clinical colitis activity index values) in patients with UC. CONCLUSIONS: Vitamin D deficiency is common in patients with IBD. However, certain clinical situations lead to significantly lower vitamin D levels and may therefore require close monitoring for vitamin D deficiency. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VITAMIN D
*DRUG therapy
*AZATHIOPRINE
*FAT-soluble vitamins
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 17512972
- Volume :
- 19
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Digestive Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 128148232
- Full Text :
- https://doi.org/10.1111/1751-2980.12565