Back to Search
Start Over
Investigation of autoantibodies to SP-1 in Chinese patients with primary Sjögren's syndrome.
- Source :
-
Clinical Immunology . Mar2018, Vol. 188, p58-63. 6p. - Publication Year :
- 2018
-
Abstract
- In order to evaluate autoantibody to SP-1 as an early biomarker in pSS, we investigated autoantibody to SP-1 in Chinese patients with primary Sjögren's syndrome (pSS). Autoantibodies to SP-1 are significantly increased in pSS patients compared to RA patients, SLE patients, and healthy people without secondary SS. The presence of anti SP-1 antibodies was negatively correlated with the focus score (FS), RF, and salivary gland function. It was positively correlated with FS = 0, RF ≤ 20, and normal salivary gland function. In further studies, the autoantigen SP-1 was identified in ductal epithelia of salivary glands in il14α TG mice by IIF. SP-1 mRNAs expression increased with growing age in il14α TG mice. SP-1 mRNA was also identified in labial biopsies of patients with pSS. In conclusion, autoantibody to SP-1 is an early marker in pSS. It is useful to diagnose pSS patients who lack RF or antibodies to Ro/La. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15216616
- Volume :
- 188
- Database :
- Academic Search Index
- Journal :
- Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 128167090
- Full Text :
- https://doi.org/10.1016/j.clim.2017.12.008