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One-step synthesis of an 18F-labeled boron-derived methionine analog: a substitute for 11C-methionine?
- Source :
-
European Journal of Nuclear Medicine & Molecular Imaging . Apr2018, Vol. 45 Issue 4, p582-584. 3p. 1 Diagram. - Publication Year :
- 2018
-
Abstract
- Amino acid-based tracers have been extensively investigated for positron emission tomography (PET) imaging of brain tumors, and 11C-methionine (11C-MET) is one of the most extensively investigated. However, widespread clinical use of 11C-MET is challenging due to the short half-life of 11C and low radiolabeling yield. In this issue of the <italic>European Journal of Nuclear Medicine and Molecular Imaging</italic>, Yang and colleagues report an 18F-labeled boron-derived methionine analog, 18F-B-MET, as a potential substitute for 11C-MET in PET imaging of glioma. The push-button synthesis, highly efficient radiolabeling, and good imaging performance in glioma models make this tracer a promising candidate for future clinical translation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16197070
- Volume :
- 45
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- European Journal of Nuclear Medicine & Molecular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 128228184
- Full Text :
- https://doi.org/10.1007/s00259-017-3927-6