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Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.
- Source :
-
European Journal of Medicinal Chemistry . Mar2018, Vol. 148, p279-290. 12p. - Publication Year :
- 2018
-
Abstract
- To improve the druggability of salinomycin, a 20-epi-amino-20-deoxysalinomycin derivatives library was synthesized with high efficacy from which a few salinomycin derivatives with high potency and selectivity were identified through comprehensive cytotoxicity assay, including a fluorine-19 magnetic resonance sensitive tool molecule. Using a K-ras cellular model, salinomycin and its derivatives showed different molecular mode of action from literature reports. These results would be valuable for developing salinomycin-based cancer therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02235234
- Volume :
- 148
- Database :
- Academic Search Index
- Journal :
- European Journal of Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 128278686
- Full Text :
- https://doi.org/10.1016/j.ejmech.2018.02.004