Diaporthols A and B: Bioactive diphenyl ether derivatives from an endophytic fungus Diaporthe sp.

Authors :: Nakashima, Ken-ichi
Tomida, Junko
Kamiya, Tetsuro
Hirai, Takao
Morita, Yuji
Hara, Hirokazu
Kawamura, Yoshiaki
Adachi, Tetsuo
Inoue, Makoto
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Mar2018, Vol. 59 Issue 13, p1212-1215. 4p.
Publication Year :: 2018
Abstract: Diaporthols A ( 1 ) and B ( 2 ), two diphenyl ether derivatives, were isolated from cultures of an endophytic fungus Diaporthe sp. ECN-137 obtained from the leaves of Phellodendron amurense . The structures of 1 and 2 were determined by extensive spectroscopic analyses, and the structure of 2 was confirmed by X-ray crystallographic analysis. Compounds 1 and 2 showed anti-migration activities in TGF-β1-elicited MDA-MB-231 breast cancer cells at a concentration of 20 μM. [ABSTRACT FROM AUTHOR]

Subjects :: *ENDOPHYTIC fungi
*ENDOPHYTES
*BIOACTIVE compounds
*BIOSYNTHESIS
*X-ray crystallography

Language :: English
ISSN :: 00404039
Volume :: 59
Issue :: 13
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 128286755
Full Text :: https://doi.org/10.1016/j.tetlet.2018.02.032

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