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Efficient α-chlorination of carbonyl containing compounds under basic conditions using methyl chlorosulfate.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Mar2018, Vol. 59 Issue 13, p1233-1238. 6p. - Publication Year :
- 2018
-
Abstract
- An efficient method for the α-chlorination of ketones under basic conditions is described using methyl chlorosulfate. Its applicability for the chlorination of other functional groups has also been studied and it is equally useful for the synthesis of α-chloroesters and amides. Methyl chlorosulfate is described for the first time as a positive chlorine source. Some aldol reactions which occur during the chlorination of some substrates are also reported. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARBONYL compounds
*METHYL acrylate
*KETONES
*ORGANIC compounds
*CHLORINATION
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 59
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 128286758
- Full Text :
- https://doi.org/10.1016/j.tetlet.2018.02.036