(Radio)fluoroclick Reaction Enabled by a Hydrogen‐Bonding Cluster.

Authors :: Zeng, Xiaojun
Xu, Bo
Li, Junling
Ng, Chin K.
Hammond, Gerald B.
Source :: Angewandte Chemie International Edition. 3/5/2018, Vol. 57 Issue 11, p2924-2928. 5p.
Publication Year :: 2018
Abstract: Abstract: We have developed a widely applicable nucleophilic (radio)fluoroclick reaction of ynamides with readily available and easy‐to‐handle KF(18F). The reactions exhibited high functional‐group tolerance and needed only an ambient atmosphere. This 18F addition to C−C unsaturated bonds proceeded with extraordinarily high radiochemical yields. [ABSTRACT FROM AUTHOR]