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Strategy To Prepare 3-Bromo- and 3-Chloropyrazoles.
- Source :
-
Journal of Organic Chemistry . 3/2/2018, Vol. 83 Issue 5, p2830-2839. 10p. - Publication Year :
- 2018
-
Abstract
- A general strategy to prepare substituted 3-bromo- and 3-chloropyrazoles is described. The three-step method involves condensation of crotonates or β-chloro carboxylic acids with hydrazines, followed by halogenation and oxidation. Several condensation and oxidation protocols were developed to enable preparation of a wide variety of 3-halopyrazoles with good to excellent yields and regiocontrol. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 83
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 128354874
- Full Text :
- https://doi.org/10.1021/acs.joc.7b03282