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Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by Plasmodium falciparum.
Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by Plasmodium falciparum.
- Source :
-
Blood . 3/8/2018, Vol. 131 Issue 10, p1111-1121. 11p. - Publication Year :
- 2018
-
Abstract
- Effective vaccines against malaria caused by Plasmodium falciparum are still lacking, and the molecular mechanism of the host-parasite interaction is not fully understood. Here we demonstrate that the interaction of RAP2, a parasite-secreted rhoptry protein that functions in the parasitophorous vacuole formation stage of the invasion, and CD147 on the host erythrocyte is essential for erythrocyte invasion by P falciparum and is independent from all previously identified interactions involved. Importantly, the blockade of the CD147-RAP2 interaction by HP6H8, a humanized CD147 antibody, completely abolished the parasite invasion with both cure and preventative functions in a humanized mouse model. Together with its long half-life on human red blood cells and its safety profile in cynomolgus monkeys, HP6H8 is the first antibody that offers an advantageous approach by targeting a more conserved late-stage parasite ligand for preventing as well as treating severe malaria. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PLASMODIUM falciparum
*ERYTHROCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 00064971
- Volume :
- 131
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 128368009
- Full Text :
- https://doi.org/10.1182/blood-2017-08-802918