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Biomimetic Copper Sulfide for Chemo-Radiotherapy: Enhanced Uptake and Reduced Efflux of Nanoparticles for Tumor Cells under Ionizing Radiation.
- Source :
-
Advanced Functional Materials . 2/28/2018, Vol. 28 Issue 9, p1-11. 11p. - Publication Year :
- 2018
-
Abstract
- Combined chemo-radiotherapy is one of most widely applied treatments for clinical cancer therapy. Herein, it is found in this carefully designed study that ionizing radiation (e.g., X-ray) can significantly increase the cell uptake of many different types of nanoparticles, and meanwhile obviously reduce their efflux. Such a phenomenon, which is not observed for small molecule drug such as doxorubicin (DOX), may be attributed to the X-ray-induced cell cycle change and upregulation of Caveolin-1, a key protein in the caveolindependent endocytosis pathway. Biomimetic copper sulfide nanoparticles, which are synthesized using melanin as the template and functionalized with polyethylene glycol (PEG), are then chosen as a platform for the combined chemo-radiotherapy. Such CuS@Melanin-PEG nanoparticles, while being able to load chemotherapeutics (e.g., DOX), can also act as a radiosensitizer to promote X-ray induced cell apoptosis. In addition, although the overall tumor accumulation of CuS@Melanin-PEG/DOX post intravenous injection is not significantly changed for tumors exposed to X-ray, X-ray radiation can result in obviously increased tumor cell uptake of drug-loaded nanoparticles, subsequently leading to excellent synergistic antitumor therapeutic effect. A nanoplatform is developed with great performance in chemo-radiotherapy, as well as uncovers a general synergistic mechanism particularly suitable for nanoparticle-based chemo-radiotherapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1616301X
- Volume :
- 28
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Advanced Functional Materials
- Publication Type :
- Academic Journal
- Accession number :
- 128373147
- Full Text :
- https://doi.org/10.1002/adfm.201705161