Back to Search
Start Over
Linagliptin potentiates the effect of l-dopa on the behavioural, biochemical and immunohistochemical changes in experimentally-induced Parkinsonism: Role of toll-like receptor 4, TGF-β1, NF-κB and glucagon-like peptide 1.
- Source :
-
Physiology & Behavior . May2018, Vol. 188, p108-118. 11p. - Publication Year :
- 2018
-
Abstract
- Objective Our aim was to assess the effect of different doses of linagliptin with or without l -dopa/Carbidopa on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in mice. Methods Eighty Balb/c mice were divided into 8 equal groups: Control; MPTP; MPTP + l -dopa/Carbidopa; MPTP + linagliptin 3 mg/kg/day; MPTP + linagliptin 10 mg/kg/day; MPTP + Carboxymethyl cellulose; MPTP + l -dopa/Carbidopa + linagliptin 3 mg/kg/day and MPTP + l -dopa/Carbidopa + linagliptin 10 mg/kg/day. Striatal dopamine, tumor necrosis factor alpha (TNF-α), interleukin 10 (IL-10), transforming growth factor beta 1 (TGF-β1), toll-like receptor 4 (TLR4), antioxidant enzymes, adenosine triphosphate (ATP), glucagon-like peptide-1 (GLP-1), receptors of advanced glycation end products (RAGE), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), heme oxygenase-1 (HO-1), mitochondrial complex I activity, catalepsy and total swim scores were measured. Also, the substantia nigra was subjected to immunohistochemical examination. Results The combination of l -dopa/Carbidopa and linagliptin in a dose-dependent manner resulted in significant improvement of the behavioural changes, striatal dopamine, antioxidant parameters, Nrf2/HO-1 content, GLP-1, ATP and mitochondrial complex I activity with significant decrease in striatal RAGE, TGF-β1, TNF-α, IL-10, TLR4 and alleviated the immunohistochemical changes better than the groups that received either l -dopa/Carbidopa or linagliptin alone. Conclusion The combination of l -dopa/Carbidopa and linagliptin might represent a promising therapeutic modality for management of parkinsonism. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00319384
- Volume :
- 188
- Database :
- Academic Search Index
- Journal :
- Physiology & Behavior
- Publication Type :
- Academic Journal
- Accession number :
- 128394904
- Full Text :
- https://doi.org/10.1016/j.physbeh.2018.01.028