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Binuclear gadolinium(III) complex based on DTPA and 1,3-bis(4-aminophenyl)adamantane as a high-relaxivity MRI contrast agent.
- Source :
-
Polyhedron . May2018, Vol. 145, p141-146. 6p. - Publication Year :
- 2018
-
Abstract
- A novel dimeric gadolinium(III) complex, bis(4-Gd-DTPA-aminophenyl)adamantane ( 5 ), was successfully synthesized using bis(4-aminophenyl)adamantane to link two Gd-DTPA units. All the intermediates and bis(4-Gd-DTPA-aminophenyl)adamantane ( 5 ) have been characterized by 1 H NMR, 13 C NMR, ES-API-MS, HR-ESI-MS, FT-IR and elemental analysis (EA). The longitudinal relaxivity of bis(4-Gd-DTPA-aminophenyl)adamantane is 8.43 mM −1 Gd −1 s −1 at 0.43 T (32 °C, pH 7.0), and 4.89 mM −1 Gd −1 s −1 at 3.0 T (32 °C, pH 7.4). The T 1 -weighted imaging in vitro showed that bis(4-Gd-DTPA-acetylaminophenyl)adamantane can enhance the contrast of images distinctly. But most of all, the kinetic inertness of bis(4-Gd-DTPA-aminophenyl)adamantane ( 5 ) was comparable to that of [Gd(DTPA)(H 2 O)] 2− (Magnetvist®). Moreover, cytotoxicity tests indicated that the bis(4-Gd-DTPA-acetylaminophenyl)adamantane exhibited low toxicity to healthy liver cells (L-02 cells). These results demonstrate that the Gd(III) complex 5 may be a promising MRI contrast agent candidate. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02775387
- Volume :
- 145
- Database :
- Academic Search Index
- Journal :
- Polyhedron
- Publication Type :
- Academic Journal
- Accession number :
- 128519148
- Full Text :
- https://doi.org/10.1016/j.poly.2018.01.032