INVESTIGATION OF PLASMA SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) AND BCL‐2 ASSOCIATED X PROTEIN (BAX) LEVELS IN RATS FED HIGH FAT AND HIGH SUCROSE DIET.

Introduction: Consumption of a diet high in saturated fats and sucrose is an important factor in the increasing occurrence of these metabolic disorders. Signal transducer and activator of transcription 3 (STAT3) and Bcl‐2 associated X protein (Bax) are multifunctional protein that are important for immune responses, cell survival, apoptosis, and proliferation. However, ıt is unknown about the relationship between the STAT3/ Bax and high sucrose/ high fat diet Material and Methods: Konya Necmettin Erbakan University, KONÜDAM Experimental Medicine Research and Application Center which was available from 28 adult Wistar albino postnatal (8‐12 weeks) male rats fed, accompanied by a high‐fat, high‐sucrose or standard chow. It was divided into several groups, in its blood (plasma) STAT3 and Bax levels were studied with the ELISA method. Results: Plasma STAT levels of fed with standard feed, fed with high sucrose diet, fed with high fat diet and fed with high fat and high sucrose diet were found as (X + SD) 0.25 ± 0.007, 0.26 ± 0.02, 0.27 ± 0.02 and 0.29 ± 0.04 pg/ml respectively. Plasma Bax levels of fed with standard feed, fed with high sucrose diet, fed with high fat diet and fed with high fat and high sucrose diet were found as (X + SD) 0.35 ± 0.02, 0.34 ± 0.02, 0.35 ± 0.01 and 0.33 ± 0.01 ng/ml respectively. There were no significant differences between plasma STAT3/ Bax levels of the groups. Discussion: Our findings show that there was no relationship between the STAT3/ Bax and high sucrose/ high fat diet. [ABSTRACT FROM AUTHOR]