RELATION BETWEEN THIOL GROUPS AND AGING.

Introduction: Aging is a basic biological process. There are numerous irreversible changes in metabolism in the aging process. One of the most important of these is the accumulation of damage products caused by reactive oxygen species (ROS) formed during metabolism. Oxidative stress occurs when the balance between antioxidants and ROS are disrupted. The human body contains various antioxidants, such as thiol, which serve to balance the effects of oxidants. Thiols are a class of organic compound that contain sulfhydryl (‐SH) group formed by combination of a hydrogen and a sulfur atom with a carbon atom. In this study, the effect of aging on thiol exchange was studied. Material and Method: The patients' thiol levels were screened retrospectively between for the last 4 months in laboratuary information system of Ataturk Training and Research Hospital. A total of 2568 patients were included in this study. Patients were divided into 4 groups according to their age. (Grup1: 1‐25, grup 2: 26‐50, grup 3: 51‐75, grup 4:76‐100). IBM SPSS 23.0 Statistical Program was used for the analysis. Results: The results showed a statistically significant difference between thiol levels and aging period in all grups (p <0.0001). Discussion: In recent years, research on aging has focused more on oxidative stress and has been suggested to play an important role in the aging process. In our study, the reduction of antioxidant capacity with aging was shown by the increase in age and the decrease in the amount of serum thiol. [ABSTRACT FROM AUTHOR]