Enantioselective total synthesis of β-zearalenol from (<italic>s</italic>)-propylene oxide.

The total synthesis of 14-membered resorcylic acid macrolide, β-zearalenol, was accomplished starting from commercially available enantiomerically pure propylene oxide and methyl 2,4-dihydroxy-6-methylbenzoate using Grignard reaction, asymmetric dihydroxylation, Yamaguchi macrolactonization, and ring-closing metathesis as key steps. [ABSTRACT FROM AUTHOR]