Chemically modified carbon based electrodes for the detection of reduced glutathione.

The early diagnosis of cataract formation, alcoholism, chronic renal failure, Parkinson’s disease, Alzheimer’s disease, malignant disorders, ageing, arthritis, epilepsy and diabetes plays a critical role in the clinical treatment. Therefore, there is an intensive research for the determination of reduced glutathione (GSH) in human blood serum. In order to protect human health from these pathophysiologic conditions, it is very important to design and develop simple, sensitive and rapid sensors for GSH detection and quantifying GSH concentrations in human blood serum. In this context, electrochemical GSH sensors appear promising among all GSH sensors in which electrode material and architecture play major roles in achieving stable and sensitive detection. This review is focussed on the use of various carbon electrodes like glassy carbon, carbon paste, carbon microfiber, basal plane pyrolytic graphite and screen-printed electrodes in the electrochemical detection of GSH. Finally, the analytical applications of carbon electrodes based electrochemical sensors for glutathione electroanalysis are discussed. [ABSTRACT FROM AUTHOR]