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Risk of stroke in patients with dengue fever: a population-based cohort study.
- Source :
-
Canadian Medical Association Journal (CMAJ) . 3/12/2018, Vol. 190 Issue 10, pE285-E290. 6p. 1 Diagram, 3 Charts. - Publication Year :
- 2018
-
Abstract
- <bold>Background: </bold>Stroke is a severe neurologic complication of dengue fever, described in only a few case reports. The incidence and risk factors for stroke in patients with dengue remain unclear. We conducted a population-based retrospective cohort study to investigate the risk of stroke in patients with dengue.<bold>Methods: </bold>Using data from the Taiwan National Health Insurance Research Database, we included a total of 13 787 patients with dengue newly diagnosed between 2000 and 2012. The control cohort consisted of patients who did not have dengue, matched 1:1 by demographic characteristics and stroke-related comorbidities. We calculated the cumulative incidences and hazard ratios (HRs) of stroke in both cohorts using Kaplan-Meier curves and Cox proportional hazards regression.<bold>Results: </bold>The overall incidence rate of stroke was 5.33 per 1000 person-years in the dengue cohort and 3.72 per 1000 person-years in the control cohort, with an adjusted HR of 1.16 (95% confidence interval [CI] 1.01-1.32). The risk of stroke among patients with dengue was highest in the first 2 months after diagnosis (25.53 per 1000 person-years, adjusted HR 2.49, 95% CI 1.48-4.18).<bold>Interpretation: </bold>Dengue fever was associated with an increased risk of stroke in the first few months after diagnosis. The effect of dengue on stroke may be acute rather than chronic. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- Volume :
- 190
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Canadian Medical Association Journal (CMAJ)
- Publication Type :
- Academic Journal
- Accession number :
- 128601683
- Full Text :
- https://doi.org/10.1503/cmaj.170994