Rh(III)-catalyzed C–H activation-desymmetrization of diazabicycles using enol as directing group: A straightforward approach to difunctionalized cyclopentenes.

A Rh(III)-catalyzed C–H activation-desymmetrization of diazabicycles with o -vinylphenols as an efficient approach to alkenyl-substituted aminocyclopentenes is reported. This protocol represents another classic example for direct C–H activation of terminal alkenes using enol as directing group. The reaction features the ease of the preparation of starting materials, fast and high efficiency, broad substrate scope and 100% atom economy, thus provides a valuable entry to synthesize novel substituted cyclopentenes. [ABSTRACT FROM AUTHOR]