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Optical Voltage Sensing Using DNA Origami.
- Source :
-
Nano Letters . 3/14/2018, Vol. 18 Issue 3, p1962-1971. 10p. - Publication Year :
- 2018
-
Abstract
- We explore the potential of DNA nanotechnology for developing novel optical voltage sensing nanodevices that convert a local change of electric potential into optical signals. As a proof-of-concept of the sensing mechanism, we assembled voltage responsive DNA origami structures labeled with a single pair of FRET dyes. The DNA structures were reversibly immobilized on a nanocapillary tip and underwent controlled structural changes upon application of an electric field. The applied field was monitored through a change in FRET efficiency. By exchanging the position of a single dye, we could tune the voltage sensitivity of our DNA origami structure, demonstrating the flexibility and versatility of our approach. The experimental studies were complemented by coarse-grained simulations that characterized voltage-dependent elastic deformation of the DNA nanostructures and the associated change in the distance between the FRET pair. Our work opens a novel pathway for determining the mechanical properties of DNA origami structures and highlights potential applications of dynamic DNA nanostructures as voltage sensors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15306984
- Volume :
- 18
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Nano Letters
- Publication Type :
- Academic Journal
- Accession number :
- 128692377
- Full Text :
- https://doi.org/10.1021/acs.nanolett.7b05354