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Folic acid-conjugated green luminescent carbon dots as a nanoprobe for identifying folate receptor-positive cancer cells.
- Source :
-
Talanta . Jun2018, Vol. 183, p39-47. 9p. - Publication Year :
- 2018
-
Abstract
- Early diagnosis is pivotal in subsequent prognosis and treatment of cancer. Herein, folic acid-conjugated carbon dots (FA-CDs) as a fluorescent nanoprobe were fabricated for identifying cancer cells visually. Green luminescent carbon dots (CDs) from active dry yeast (ADY) were readily prepared in scale-up to reach macroscopic production with a high yield of ~50% via a facile and rapid microwave approach. The as-prepared CDs were further combined with folic acid (FA) by covalent bonding to fabricate the FA-CDs for identification of cancer cells over-expressing folate receptor (FR). Experimental outcomes demonstrated that the resultant FA-CDs noninvasively entered into cancer cells via receptor-mediated endocytosis and could differentiate FR-positive HepG2 cells from a cell mixture by fluorescence imaging, which suggests a promising prospect of the FA-CDs as an efficient probe for cancer diagnosis and succeeding personalized therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FOLIC acid
*VITAMIN B complex
*CANCER cells
*ENDOCYTOSIS
*FLUORESCENCE
Subjects
Details
- Language :
- English
- ISSN :
- 00399140
- Volume :
- 183
- Database :
- Academic Search Index
- Journal :
- Talanta
- Publication Type :
- Academic Journal
- Accession number :
- 128718833
- Full Text :
- https://doi.org/10.1016/j.talanta.2018.02.009