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Organization of the Monocyte/Macrophage System of Normal Human Skin.
- Source :
-
Journal of Investigative Dermatology . Jul90, Vol. 95 Issue 1, p83-89. 7p. - Publication Year :
- 1990
-
Abstract
- Monocytes and macrophages are known to be important for a variety of functions; however, whereas epidermal Langerhans cells have been studied in great detail, few data are available for the dermal monocyte/macrophage system. Therefore we investigated the density, distribution, and phenotype of dermal macrophages in normal human skin using a panel of monoclonal antibodies for single and double labeling. We demonstrate here that within normal human dermis macrophages reside with a remarkable density. Principally, these cells exhibit the phenotype of the phagocytic macrophage system (CD11c+, KiM8+), whereas members of the immune phagocyte system (CD11c+, KiM8-) are absent from normal dermis with the exception of a few Langerhans cells in the papillary body. Within the dermal phagocytic macrophage system we uncover an unexpected phenotypical and morphologic heterogeneity, which correlates with the tissue localization. This study provides a basis for investigating the participation and change of the dermal macrophage system in cutaneous disorders. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MONOCYTES
*SKIN
*MACROPHAGES
*LEUCOCYTES
*RETICULO-endothelial system
*PHAGOCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 0022202X
- Volume :
- 95
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Investigative Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 12874002
- Full Text :
- https://doi.org/10.1111/1523-1747.ep12874002