Back to Search Start Over

Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal.

Authors :
Isidro, Joana
Santos, Andrea
Nunes, Alexandra
Borges, Vítor
Silva, Catarina
Vieira, Luís
Mendes, Aristides L.
Serrano, Mónica
Henriques, Adriano O.
Gomes, João Paulo
Oleastro, Mónica
Source :
Emerging Infectious Diseases. Apr2018, Vol. 24 Issue 4, p741-745. 5p. 2 Diagrams, 2 Charts.
Publication Year :
2018

Abstract

We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*IMIPENEM
*BETA lactam antibiotics
*CLOSTRIDIOIDES difficile
*PENICILLIN-binding protein genetics
*DRUG resistance in microorganisms
*AMINO acids
*ANTIBIOTICS
*BACTERIOPHAGE typing
*COMPARATIVE studies
*BIOLOGICAL evolution
*GENOMES
*RESEARCH methodology
*MEDICAL cooperation
*MICROBIAL sensitivity tests
*GENETIC mutation
*RESEARCH
*EVALUATION research
*PSEUDOMEMBRANOUS enterocolitis
*PHARMACODYNAMICS

Details

Language :
English
ISSN :
10806040
Volume :
24
Issue :
4
Database :
Academic Search Index
Journal :
Emerging Infectious Diseases
Publication Type :
Academic Journal
Accession number :
128748710
Full Text :
https://doi.org/10.3201/eid2404.170095
Full Text Access
View/download PDF

Tools

Authors Abstract Subjects Details