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The Role of Adhesion Molecules in Epithelial-T-Cell Interactions in Thymus and Skin.
- Source :
-
Journal of Investigative Dermatology . Jun90 Supplement, Vol. 94, p85s-90s. 6p. - Publication Year :
- 1990
-
Abstract
- Interaction of T lymphocytes with other cell types is important for normal T-cell development and function. Recently, a number of adhesion molecules important in T-cell interactions with other cell types have been defined. In this paper we review the role of two adhesion pathways, CD2/LFA-3 and LFA-1/ICAM-1, in T-cell interactions with epithelial cells of the thymus and skin. While thymic epithelium-T-cell interactions were mediated by both the LFA-1/ICAM-1 pathway and the CD2/LFA-3 pathway, epidermal-T-cell interactions were mediated primarily by the LFA-1/ICAM-1 pathway. Although ICAM-1 was not expressed in vivo on epidermal keratinocytes in normal skin, ICAM-1 was expressed by epidermal keratinocytes at the site of T-cell infiltration in inflammatory dermatitis. ICAM-1 was expressed in vivo on thymic epithelium. Both LFA-3 and ICAM-1 were expressed on epithelial cells of thymus and skin early on in fetal ontogeny. These antigen-independent adhesion molecules play an important role in the cell-cell interactions associated with T-cell differentiation and function. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL adhesion molecules
*T cells
*THYMUS
*SKIN
*EPITHELIUM
*CELL adhesion
Subjects
Details
- Language :
- English
- ISSN :
- 0022202X
- Volume :
- 94
- Database :
- Academic Search Index
- Journal :
- Journal of Investigative Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 12876038
- Full Text :
- https://doi.org/10.1111/1523-1747.ep12876038