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High expression of A-type lamin in the leading front is required for Drosophila thorax closure.
- Source :
-
Biochemical & Biophysical Research Communications . May2018, Vol. 499 Issue 2, p209-214. 6p. - Publication Year :
- 2018
-
Abstract
- Tissue closure involves the coordinated unidirectional movement of a group of cells without loss of cell–cell contact. However, the molecular mechanisms controlling the tissue closure are not fully understood. Here, we demonstrate that Lamin C, the sole A-type lamin in Drosophila , contributes to the process of thorax closure in pupa. High expression of Lamin C was observed at the leading front of the migrating wing imaginal discs. Live imaging analysis revealed that knockdown of Lamin C in the thorax region affected the coordinated movement of the leading front, resulting in incomplete tissue fusion required for formation of the adult thorax. The closure defect due to knockdown of Lamin C correlated with insufficient accumulation of F-actin at the front. Our study indicates a link between A-type lamin and the cell migration behavior during tissue closure. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DROSOPHILA
*F-actin
*RNA interference
*PHALLOIDINE
*GENE expression
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 499
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 128787303
- Full Text :
- https://doi.org/10.1016/j.bbrc.2018.03.128