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CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4+T lymphocytes.
- Source :
-
Cell Death & Differentiation . May2004, Vol. 11 Issue 5, p574-582. 9p. - Publication Year :
- 2004
-
Abstract
- CD95(APO-1/Fas)-mediated apoptosis of bystander uninfected T cells exerts a major role in the HIV-1-mediated CD4+ T-cell depletion. HIV-1 gp120 has a key role in the induction of sensitivity of human lymphocytes to CD95-mediated apoptosis through its interaction with the CD4 receptor. Recently, we have shown the importance of CD95/ezrin/actin association in CD95-mediated apoptosis. In this study, we explored the hypothesis that the gp120-mediated CD4 engagement could be involved in the induction of susceptibility of primary human T lymphocytes to CD95-mediated apoptosis through ezrin phosphorylation and ezrin-to-CD95 association. Here, we show that gp120/IL-2 combined stimuli, as well as the direct CD4 triggering, on human primary CD4+T lymphocytes induced an early and stable ezrin activation through phosphorylation, consistent with the induction of ezrin/CD95 association and susceptibility to CD95-mediated apoptosis. Our results provide a new mechanism through which HIV-1-gp120 may predispose resting CD4+T cell to bystander CD95-mediated apoptosis and support the key role of ezrin/CD95 linkage in regulating susceptibility to CD95-mediated apoptosis.Cell Death and Differentiation (2004) 11, 574-582. doi:10.1038/sj.cdd.4401374 Published online 23 January 2004 [ABSTRACT FROM AUTHOR]
- Subjects :
- *HYPOTHESIS
*APOPTOSIS
*T cells
*DISEASE susceptibility
*PHOSPHORYLATION
*CD4 antigen
Subjects
Details
- Language :
- English
- ISSN :
- 13509047
- Volume :
- 11
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Cell Death & Differentiation
- Publication Type :
- Academic Journal
- Accession number :
- 12887110
- Full Text :
- https://doi.org/10.1038/sj.cdd.4401374