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Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells.
- Source :
-
Bioorganic & Medicinal Chemistry . May2018, Vol. 26 Issue 8, p1776-1783. 8p. - Publication Year :
- 2018
-
Abstract
- Unlike reported bisindoles linked by single bond directly, alstoniasidines A ( 1 ) and B ( 2 ), from Alstonia scholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented a novel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibited selective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsic apoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF-α), and the cleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. This finding might provide new type of leads for the selective killing of human glioma stem cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 26
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 128922384
- Full Text :
- https://doi.org/10.1016/j.bmc.2018.02.024