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High energy transition state complex increased anticancer activity: A case study on CuII-complexes.
- Source :
-
Inorganic Chemistry Communications . May2018, Vol. 91, p119-123. 5p. - Publication Year :
- 2018
-
Abstract
- The different anticancer activities of two Cu (II) -complexes are reported: 1) containing acetylacetonate (acac), NO 3 − and 2,9-dimethyl-1,10-phenanthroline (2,9-dmp), 2) containing acetylacetonate (acac), NO 3 − and 1,10-phenanthroline (phen). Cytotoxicity test shown that complex 1 has much higher inhibition rate than complex 2 especially, higher than the famous anticancer drug 5-Fu. In this paper, we associated the bond length of complexes with their anticancer activity, and demonstrated that (1) in water solution the bonds of L-Cu II (2,9-dmp) will neither stay coordinated nor break up completely, but change into a transition state with weaker linkage than those in a solid state; (2) the superior anticancer activates of complex 1 correspond to the increased flexibility between ligand and Cu II as the bond length was elongated in solution; (3) The high energy transition State of complex 1 in water solution is more effective in oxidizing O 2 − into O 2 than complex 2 . [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13877003
- Volume :
- 91
- Database :
- Academic Search Index
- Journal :
- Inorganic Chemistry Communications
- Publication Type :
- Academic Journal
- Accession number :
- 128922729
- Full Text :
- https://doi.org/10.1016/j.inoche.2018.03.005