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Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer.
- Source :
-
Digestive Diseases & Sciences . May2018, Vol. 63 Issue 5, p1229-1236. 8p. - Publication Year :
- 2018
-
Abstract
- <bold>Background: </bold>The fatty acid profile of the fecal metabolome and its association with colorectal cancer (CRC) has not been fully evaluated.<bold>Aims: </bold>We aimed to compare the fecal fatty acid profiles of CRC patients and healthy controls.<bold>Methods: </bold>We enrolled 26 newly diagnosed CRC patients and 28 healthy individuals between July 2014 and August 2014 from our institute. Long- and short-chain fatty acids were extracted from fecal samples and analyzed using gas chromatography-mass spectrometry.<bold>Results: </bold>Regarding fecal long-chain fatty acids, the levels of total ω-6 polyunsaturated fatty acids and, particularly, of linoleic acid (C18:2ω-6) were significantly higher in male CRC patients than in healthy men (2.750 ± 2.583 vs. 1.254 ± 0.966 µg/mg feces, P = 0.040; 2.670 ± 2.507 vs. 1.226 ± 0.940 µg/mg feces, P = 0.034, respectively). In addition, the levels of total monounsaturated fatty acid and, particularly, of oleic acid (C18:1ω-9) were significantly higher in male CRC patients than in healthy men (1.802 ± 1.331 vs. 0.977 ± 0.625 µg/mg feces, P = 0.027; 1.749 ± 1.320 vs. 0.932 ± 0.626 µg/mg feces, P = 0.011, respectively). However, those differences were not shown in female gender. The level of fecal short-chain fatty acids was not different between CRC patients and healthy controls.<bold>Conclusions: </bold>There were changes in the profiles of fecal fatty acid metabolomes in CRC patients compared to healthy controls, implying that fecal fatty acids could be used as a novel screening tool for CRC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COLON cancer patients
*TUMOR markers
*FATTY acids
*FECAL analysis
*MEDICAL screening
*METABOLOMICS
*COLON tumors
*COMPARATIVE studies
*FECES
*GAS chromatography
*LONGITUDINAL method
*MASS spectrometry
*MEDICAL cooperation
*METABOLISM
*RESEARCH
*LOGISTIC regression analysis
*PILOT projects
*EVALUATION research
*CASE-control method
*EARLY detection of cancer
*DIAGNOSIS
RECTUM tumors
Subjects
Details
- Language :
- English
- ISSN :
- 01632116
- Volume :
- 63
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Digestive Diseases & Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 129021243
- Full Text :
- https://doi.org/10.1007/s10620-018-4982-y