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miR-519d-3p Inhibits Cell Proliferation and Invasion of Gastric Cancer by Downregulating B-Cell Lymphoma 6.
- Source :
-
Cytogenetic & Genome Research . Apr2018, Vol. 154 Issue 1, p12-19. 8p. 5 Graphs. - Publication Year :
- 2018
-
Abstract
- miR-519d inhibits cell growth, migration, and invasion, but its role in gastric cancer (GC) cells is obscure. We showed that miR-519d-3p was lowly expressed in GC tissues and was associated with the clinical stage and lymph node metastasis of GC tissues. We found that miR-519d-3p repressed cell proliferation and invasion of MGC803 cells and delayed the G1/S phase transition, resulting in decreased cyclin B1 and MMP2 and increased E-cadherin levels. Furthermore, miR-519d-3p targeted and downregulated B-cell lymphoma 6 (BCL6) expression. BCL6 overexpression partially abrogated the suppressive function of miR-519d in MGC803 cells. In conclusion, our study demonstrated that miR-519d-3p functions as a tumor suppressor by targeting and downregulating the expression of BCL6 in GC cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL proliferation
*B cells
*LYMPHOMAS
*CADHERINS
*CELL growth
Subjects
Details
- Language :
- English
- ISSN :
- 14248581
- Volume :
- 154
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cytogenetic & Genome Research
- Publication Type :
- Academic Journal
- Accession number :
- 129070757
- Full Text :
- https://doi.org/10.1159/000487372